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Delavirdine structure.jpg
IUPAC name: see chemistry section
Synonyms: SPP
Formula: C22H28N6O3S

 Uses: HIV

 Properties: Reverse Transcriptase inhibitor

 Hazards: see drug interactions

Mass (g/mol): CAS #:
456.5611 136817-59-9

Delavirdine (DLV), also called SPP, is an antiviral drug that is a non-nucleoside, reverse transcriptase inhibitor (nNRTI) specific for HIV-1. It binds directly to reverse transcriptase catalytic site and blocks the DNA polymerase activity. HIV-2 RT and eukaryotic (human, for example) DNA polymerases are not effected by this drug. Rashes are the major side effect of delavirdine toxicity, and they should be reported to the attending physician. Rashes typically are resolved in two weeks or less, but patients with severe rash or rash accompanied by fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.


Its chemical name is N-[2-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]-1H-indol- 5-yl]methanesulfonamide and its chemical formula is C22H28N6O3S (Molecular Mass 456.5611).

Drug interactions

The effect of delavirdine is decreased when used with St. John's Wort, antacids, some anticonvulsants such as carbamazepine, fosphenytoin, methylphenobarbital, phenobarbital and phentoin, and with rifampin or rifabutin. Amprenavir and derivatives (Fosamprenavir) decrease delavirdine levels.

Delavirdine increases the effects and toxicity of benzodiazepine when taken with alprazolam, midazolam or triazolam and also the effects of some statins, including atorvastatin, lovastatin and simvastatin. The toxicity of ergot may be a concern when delavirdine is taken with the ergot derivatives dihydroergotamine, dihydroergotoxine, ergonovine, ergotamine, methylergonovine, and methysergide. An increased risk of cardiotoxicity and arrhythmias are noted when delavirdine is taken with astemizole, cisapride or terfenadine. The effects of the antiviral drugs indinavir and ritonavir are increased when taken with delavirdine. Increased toxicity is also noted with quinupristin and saquinavir.

External Links

The most up-to-date information about Delavirdine and other drugs can be found at the following sites.