Simvastatin is a hydroxymethylglutaryl-coenzyme A reductase inhibitor (statin). It is a methylated derivative of lovastatin used treat hypercholesterolemia, to prevent heart attacks and strokes, and to diminish athlerosclorosis. It is structurally and functionally similar to the other class I statins mevastatin, lovastatin and pravastatin. Its IUPAC chemical name is [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl 1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate and its chemical formula is C25H38O5.
Simvastatin is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B. It inhibits the function of hydroxymethylglutaryl COA reductases, key enzymes in the production of cholesterol. It also increases LDL catabolism and may interfere with steroid production.
==Pharmacology== ===Administration=== Both the drug and its -hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.
Distribution=== ===Metabolism=== ===Excretion
Drug toxicity include
Its drug interactions include alcohol and grapefruit juice which should be avoided when taking this medication.
The most up-to-date information about Simvastatin and other drugs can be found at the following sites.