Saquinavir

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Saquinavir structure.jpg
saquinavir
IUPAC name: see Chemistry section
Synonyms: SVQ
Formula: C38H5N6O5

 Uses: HIV

 Properties: protease inhibitor

 Hazards: see drug interactions

Mass (g/mol): CAS #:
670.8408 127779-20-8



Saquinavir, abbreviated SQV and sold under the trade names Fortovase®, Invirase® and ROC®, is a protease inhibitor used to treate HIV/AIDS. It is effective againsts HIV-1 and HIV-2. Saquinavir binds to the protease active site and inhibits its activity, thus preventing cleavage of the viral polyproteins resulting in immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs and due to their short half-life, often must be taken about every four hours.

Chemistry

Its IUPAC chemical name is (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide and its chemical formula is C38H5N6O5.

External links

The most up-to-date information about Saquinavir and other drugs can be found at the following sites.