We are creating the world's most trusted encyclopedia and knowledge base. Once you join us and log in, you'll be able to edit this page instantly!

From Citizendium, the Citizens' Compendium

ritonavir
IUPAC name: see chemistry section Synonyms: Norvir®,Norvir Sec® Formula: C37H48N6O5S2
Uses:	HIV
Properties:	protease inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 720.9442 155213-67-5

Ritonavir, sold under the brand names Norvir® and Norvir Sec®, and as a mixture with Lopinavir called Kaletra®, is a protease inhibitor used to treat HIV/AIDS by disrupting the reproductive cycle of the virus. Ritonavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Protease inhibitors like ritonavir are almost always used in combination with at least two other anti-HIV drugs.

Chemistry

Its chemical name is 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan- 2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-di(phenyl)hexan- 2-yl]carbamate and its chemical formula is C₃₇H₄₈N₆O₅S₂.

External Links

• Ritonavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).

• Ritonavir - Drug information for patients from MedMaster (U.S. National Library of Medicine).

• Ritonavir - Detailed information from DrugBank.