Disease modifying anti-rheumatic drugs/Related Articles
From Citizendium, the Citizens' Compendium
Disease modifying anti-rheumatic drugs: Drugs that directly affect the underlying autoimmune processes in rheumatological disease, rather than act simply as analgesics or nonspecific antiinflammatories; they include gold compounds (e.g., aurothioglucose), antimalarials, penicillamine, and monoclonal antibodies against tumor necrosis factor-alpha and other immunochemicals
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- Rheumatology : Medical specialty that deals with the study, diagnosis, and treatment of connective tissue diseases; a subspecialty of internal medicine
- Autoimmune disease : Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
- Antimalarial : Rather than all drugs active against malaria, usually a reference to several synthetic analogues of quinine, with applications against malaria and other parasites, but also as disease modifying anti-rheumatic drugs (DMARD) used as immunomodulators in rheumatology
- Pyrimidine synthesis inhibitor : Add brief definition or description
- Tumor necrosis factor-alpha blockers : Add brief definition or description
- Interleukin-1 blockers : Add brief definition or description
- Azathioprine : An immunosuppressive purine synthesis inhibitor for treating rheumatoid arthritis; formerly a chemotherapy drug.
- Methotrexate : An inhibitor of tetrahydrofolate dehydrogenase, which prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA; it has a wide range of medical applications.
- Cyclosporin : Add brief definition or description
- Minocycline : An antibiotic tetracycline analog that can be used to treat tetracycline-resistant staphylococcus infections.
- Sulfasalazine : A sulfa drug, a derivative of Mesalazine, used primarily as an anti-inflammatory agent in the treatment of inflammatory bowel disease as well as for rheumatoid arthritis.
- Gold-based drugs : Add brief definition or description
- Glucocorticoid : Corticosteroids that affect carbohydrate metabolism, inhibit adrenocorticotropic hormone secretion, and are anti-inflammatory.
- Anti-B cell (CD20) antibody : Add brief definition or description
- Rituximab : Chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells, and used in the treatment of many lymphomas, and leukaemias.
- Blockers of T cell activation : Add brief definition or description
- Rheumatoid arthritis : A chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints.
- Systemic lupus erythematosus : Connective tissue disorder, that primarily affect women of childbearing age, have a variety of clinical forms, and are characterized by red scaly skin lesions.
- Mixed connective tissue disorder : Add brief definition or description
- Aspirin : Common analgesic used for treating mild to moderate pain; protective against blood clots and heart disease when administered indefinitely in low doses
- Trilisate : Add brief definition or description
- Acetaminophen : An analgesic antipyretic drug widely used for the treatment of headaches, fever and other minor aches and pains; has no antiinflammatory activity
- Tramadol : An atypical opioid analgesic useful for mild to moderate pain, with a potential for abuse
- Non-steroidal anti-inflammatory agent : Medication other than corticosteroids having analgesic, antipyretic and anti-inflammatory activity due to their ability to inhibit the synthesis of prostaglandins.