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Aspirin

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(CC) Image: David E. Volk Aspirin.
(CC) Image: David E. Volk
Aspirin.

Aspirin, or acetylsalicylic acid, is the "prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Specifically, it inactivates the enzyme prostaglandin synthase by acetylating its terminal amino group. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis."[1] Aspirin is a non-steroidal anti-inflammatory agent, often abbreviated as NSAID.

Aspirin resistance may cause susceptibility to cardiovascular morbidity.[2]

Contents

Aspirin resistance

Individuals in whom platelet function assays demonstrate resistance to aspirin are less likely to have cardiovascular protection from aspirin or other antiplatelet treatments.accompanied by rhinorrhea[3] As many as 28% of patients are resistant to aspirin.[4]

Asthma, Nasal Polyps, and Aspirin Intolerance

Among patients with asthma, 10% to 20% may have bronchoconstriction accompanied by rhinorrhea.[5]

External links


References

  1. ↑ Anonymous, (2008) Aspirin (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Krasopoulos, George et al. 2008. “Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis.” BMJ 336(7637):195-198. http://www.bmj.com/cgi/content/full/336/7637/195
  3. ↑ Krasopoulos G, Brister SJ, Beattie WS, Buchanan MR (2008). "Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis". BMJ 336 (7637): 195–8. DOI:10.1136/bmj.39430.529549.BE. PMID 18202034.
  4. ↑ Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 608223. World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/
  5. ↑ Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 208550. World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/
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