Myocardial revascularization

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In medicine, myocardial revascularization is "the restoration of blood supply to the myocardium."[1]

Revascularization procedures include:

Clinical practice guidelines address management and selection of patients.[5]

Coronary artery bypass is more effective for myocardial revascularization of coronary heart disease than percutaneous transluminal coronary angioplasty[6], especially for patients with diabetes who have stenosis of three coronary arteries.[7] Coronary artery bypass is also more effective than percutaneous transluminal coronary angioplasty with drug-eluting stents; however, bypass may increase the rate of stroke.[8]

The SYNTAX score may help determine choice of procedure for myocardial revascularization.[9]

"Calculation of the Society of Thoracic Surgeons (STS) and SYNTAX scores is reasonable in patients with unprotected left main and complex CAD."[5]

Of patients without indications for myocardial revascularization, cardiologists will recommended percutaneous transluminal coronary angioplasty for 21% of patients.[10] A second study found that 12% of elective percutaneous transluminal coronary angioplasties were done for inappropriate reasons.[11]

Regarding drug eluting stents, about 50% of patients received them for off-label purposes.[12][13] Patients receiving stents for off-label indications have more adverse outcomes.[12][13]


  1. Anonymous (2022), Myocardial revascularization (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Anonymous (2022), Coronary Artery Bypass (English). Medical Subject Headings. U.S. National Library of Medicine.
  3. Anonymous (2022), Percutaneous transluminal coronary angioplasty (English). Medical Subject Headings. U.S. National Library of Medicine.
  4. Anonymous (2022), Coronary Atherectomy (English). Medical Subject Headings. U.S. National Library of Medicine.
  5. 5.0 5.1 Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B et al. (2011). "2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.". Circulation. DOI:10.1161/CIR.0b013e31823ba622. PMID 22064601. Research Blogging. Cite error: Invalid <ref> tag; name "pmid22064601" defined multiple times with different content
  6. Bravata DM, Gienger AL, McDonald KM, et al (2007). "Systematic Review: The Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Surgery". Ann Intern Med. PMID 17938385[e]
  7. (July 1996) "Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. The Bypass Angioplasty Revascularization Investigation (BARI) Investigators". N. Engl. J. Med. 335 (4): 217–25. PMID 8657237[e]
  8. Serruys PW, Morice MC, Kappetein AP, et al (March 2009). "Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease". N. Engl. J. Med. 360 (10): 961–72. DOI:10.1056/NEJMoa0804626. PMID 19228612. Research Blogging.
  9. Valgimigli M, Serruys PW, Tsuchida K, et al (April 2007). "Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention". Am. J. Cardiol. 99 (8): 1072–81. DOI:10.1016/j.amjcard.2006.11.062. PMID 17437730. Research Blogging.
  10. Hannan EL, Racz MJ, Gold J, Cozzens K, Stamato NJ, Powell T et al. (2010). "Adherence of catheterization laboratory cardiologists to American College of Cardiology/American Heart Association guidelines for percutaneous coronary interventions and coronary artery bypass graft surgery: what happens in actual practice?". Circulation 121 (2): 267-75. DOI:10.1161/CIRCULATIONAHA.109.887539. PMID 20048207. Research Blogging.
  11. Chan PS, Patel MR, Klein LW, Krone RJ, Dehmer GJ, Kennedy K et al. (2011). "Appropriateness of percutaneous coronary intervention.". JAMA 306 (1): 53-61. DOI:10.1001/jama.2011.916. PMID 21730241. Research Blogging.
  12. 12.0 12.1 Win HK, Caldera AE, Maresh K, Lopez J, Rihal CS, Parikh MA et al. (2007). "Clinical outcomes and stent thrombosis following off-label use of drug-eluting stents.". JAMA 297 (18): 2001-9. DOI:10.1001/jama.297.18.2001. PMID 17488965. Research Blogging.
  13. 13.0 13.1 Beohar N, Davidson CJ, Kip KE, Goodreau L, Vlachos HA, Meyers SN et al. (2007). "Outcomes and complications associated with off-label and untested use of drug-eluting stents.". JAMA 297 (18): 1992-2000. DOI:10.1001/jama.297.18.1992. PMID 17488964. Research Blogging.