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Interleukin-2

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Interleukin-2 is an interleukin generated by T4 helper lymphocytes. It induces DNA synthesis in naive lymphocytes. Other terms include Lymphocyte Mitogenic Factor, T-Cell Growth Factor, Thymocyte Stimulating Factor and T-Cell Stimulating Factor.[1]

The gene expresses when stimulated by human T-cell leukemia virus Type 1.[2]

Thalidomide has a costimulatory or adjuvant effect on T-lymphocytes resulting in increased T-cell proliferation and increased production of interleukin-2 and interferon gamma.[3]

References

  1. Anonymous (2020), Interleukin-2 (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Jun-ichiro Inoue et al. (1986), "Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1", EMBO Journal 5 (11): 2883-2888
  3. Monograph: Thalidomide — Pharmacology, American Society of Health System Pharmacists/Medscape