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G-protein-coupled receptor

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In biology, G-protein-coupled receptors are the "largest family of cell surface receptors involved in signal transduction. They share a common structure and signal through heterotrimeric g-proteins."[1][2]

In signal transduction, cell surface receptors such as G-protein-coupled receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP and cyclic GMP which then may activate protein kinases such as G-protein-coupled receptor kinase which then affect downstream targets (see figure).[3]

Two principal signal transduction pathways involving the G-protein coupled receptors are proposed: they use either the cyclic AMP or the phosphatidylinositol diphosphate-inositol triphosphate second messenger systems.[4]

Examples of G-protein-coupled receptors include adrenergic receptors, angiotensin receptors, bradykinin receptors, CCR5 receptor (used by HIV to infect cells), opioid receptors, and purinoceptor P2Y12 (causes platelet aggregation).


  1. Anonymous (2020), G-protein-coupled receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Rosenbaum DM, Rasmussen SG, Kobilka BK (2009). "The structure and function of G-protein-coupled receptors.". Nature 459 (7245): 356-63. DOI:10.1038/nature08144. PMID 19458711. Research Blogging.
  3. Lodish, Harvey F. (1999). “20.1. Overview of Extracellular Signaling”, Molecular cell biology. New York: Scientific American Books. ISBN 0-7167-3136-3. 
  4. Gilman AG (1987). "G proteins: transducers of receptor-generated signals". Annu. Rev. Biochem. 56: 615–49. DOI:10.1146/ PMID 3113327. Research Blogging.