CD4-positive T-lymphocyte

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In medicine, the CD4-positive T-lymphocyte is "a critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes."[1]

The number of CD4-positive T-lymphocytes is called the CD4 lymphocyte count and it is reduced in AIDS.


  1. Anonymous (2021), CD4-positive T-lymphocyte (English). Medical Subject Headings. U.S. National Library of Medicine.