CD4 antigen

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In medicine, the CD4 antigens are "55-kda antigens found on helper-inducer T-lymphocytes and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in major histocompatibility complex class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as interleukin-15 receptors and bind to the HIV receptors, binding directly to the HIV envelope protein G120."[1]

The number of CD4-positive T-lymphocytes is called the CD4 lymphocyte count and it is reduced in Human Immunodeficiency Virus Type 1 and AIDS.


  1. Anonymous (2021), CD4 antigen (English). Medical Subject Headings. U.S. National Library of Medicine.