Beta 2-glycoprotein I

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In physiology, beta 2-glycoprotein (apolipoprotein H) I is "a 44-kDa highly glycosylated plasma protein that binds phospholipids including cardiolipin; apolipoprotein E receptor; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with antiphospholipid antibodies".[1]

Autoantibodies to beta 2-glycoprotein may be associated with systemic lupus erythematosus and antiphospholipid syndrome.


  1. Anonymous (2021), Beta 2-glycoprotein I (English). Medical Subject Headings. U.S. National Library of Medicine.