Antilipemic agent

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In medicine, antilipemic agents are medications for the treatment of hypercholesterolemia and hypertriglyceridemia.[1]

Classification

Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins)

For more information, see: Hydroxymethylglutaryl-coenzyme A reductase inhibitor.


Bile acid sequestrants

Fibric acid derivatives

Clofibric acid derivatives include gemfibrozil, clofibrate, and fenofibrate. Fenofibrate is unique in being able to lower the serum uric acid level and treat hyperuricemia.[2]

Plant stanols

Uses

For more information, see: Hypercholesterolemia and Hypoalphalipoproteinemia.


Adverse effects

Medications, such as the antilipemic agents atorvastatin, simvastatin, or gemfibrozil that are metabolized by cytochrome P-450 may increase bleeding when added to patients taking warfarin.[3]

References

  1. Anonymous (2015), Antilipemic agent (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Feher MD, Hepburn AL, Hogarth MB, Ball SG, Kaye SA (February 2003). "Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout". Rheumatology (Oxford) 42 (2): 321–5. PMID 12595630[e]
  3. Schelleman H, Bilker WB, Brensinger CM, Wan F, Yang YX, Hennessy S (2010). "Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding risk.". Am J Med 123 (2): 151-7. DOI:10.1016/j.amjmed.2009.07.020. PMID 20103024. PMC PMC2813204. Research Blogging.