In medicine, hyperuricemia is "excessive uric acid or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (Lesch-Nyhan Syndrome). It is associated with hypertension and gout." Niacin can increase serum uric acid levels.
Hyperuricemia may or may not be associated with vascular disease and chronic kidney disease and metabolic syndrome. If hyperuricemia is associated with vascular disease, a meta-analysis suggests that the strength of association is unlikely to be large enough for the presence of hyperuricemia to help in the prediction of vascular disease.
Randomized controlled trials suggests that treatment of hyperuricemia may:
- Slow the progression of chronic kidney disease
- Reduce hypertension
- Reduce angina pectoris.
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