Reactive arthritis

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In medicine, reactive arthritis is an "aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the gastrointestinal tract or urogenital system. The initiating trigger pathogens are usually shigella; salmonella; yersinia; campylobacter; or chlamydia trachomatis. Reactive arthritis is strongly associated with HLA-B27 antigen."[1] In simpler terms, it is an inflammation of a joint that develops after an infectiou outside a joint.

While the arthritic inflammation must be treated, a careful search must be made for remaining infection, and, if any is found, treated.


The frequency of reactive arthritis after an infection is estimated to be 0.6 to 3.1 cases/100,000.[2]


  1. Anonymous (2021), Reactive arthritis (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Townes JM, Deodhar AA, Laine ES, et al (December 2008). "Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study". Ann. Rheum. Dis. 67 (12): 1689–96. DOI:10.1136/ard.2007.083451. PMID 18272671. Research Blogging.