Metoprolol: Difference between revisions
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imported>Robert Badgett (New page: {{subpages}} In medicine, metoprolol is a adrenergic beta-antagonist that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is...) |
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In medicine, metoprolol is a [[adrenergic beta-antagonist]] that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in [[angina]] pectoris, [[hypertension]], or cardiac arrhythmias." It is also used for [[heart failure]].<ref>{{MeSH}}</ref> | In medicine, metoprolol is a [[adrenergic beta-antagonist]] that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in [[angina]] pectoris, [[hypertension]], or cardiac arrhythmias." It is also used for [[heart failure]].<ref>{{MeSH}}</ref> | ||
==Metabolism== | |||
It is metabolized by [[cytochrome P-450]] [http://www.ncbi.nlm.nih.gov/sites/entrez/?db=gene&cmd=Retrieve&dopt=summary&list_uids=1565 2D6] [[allele]] and so may have drug interactions<ref name="pmid18452693">{{cite journal |author=Onalan O, Cumurcu BE, Bekar L |title=Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine |journal=Mayo Clin. Proc. |volume=83 |issue=5 |pages=595–9 |year=2008 |month=May |pmid=18452693 |doi= |url=http://www.mayoclinicproceedings.com/Abstract.asp?AID=4681&Abst=Abstract&UID= |issn=}}</ref> and inherited variations in metabolism.<ref name="pmid16220080">{{cite journal |author=Nozawa T, Taguchi M, Tahara K, ''et al'' |title=Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol |journal=J. Cardiovasc. Pharmacol. |volume=46 |issue=5 |pages=713–20 |year=2005 |month=November |pmid=16220080 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0160-2446&volume=46&issue=5&spage=713 |issn=}}</ref> | It is metabolized by [[cytochrome P-450]] [http://www.ncbi.nlm.nih.gov/sites/entrez/?db=gene&cmd=Retrieve&dopt=summary&list_uids=1565 2D6] [[allele]] and so may have drug interactions<ref name="pmid18452693">{{cite journal |author=Onalan O, Cumurcu BE, Bekar L |title=Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine |journal=Mayo Clin. Proc. |volume=83 |issue=5 |pages=595–9 |year=2008 |month=May |pmid=18452693 |doi= |url=http://www.mayoclinicproceedings.com/Abstract.asp?AID=4681&Abst=Abstract&UID= |issn=}}</ref> and inherited variations in metabolism.<ref name="pmid16220080">{{cite journal |author=Nozawa T, Taguchi M, Tahara K, ''et al'' |title=Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol |journal=J. Cardiovasc. Pharmacol. |volume=46 |issue=5 |pages=713–20 |year=2005 |month=November |pmid=16220080 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0160-2446&volume=46&issue=5&spage=713 |issn=}}</ref> | ||
==Dosage== | |||
For healthy adults, the starting dose is 25 to 100 mg daily in single or divided doses and the maximum dose is 400 to 450 mg/day. | |||
==External links== | |||
{{CZMed}} | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 10:58, 3 January 2009
In medicine, metoprolol is a adrenergic beta-antagonist that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias." It is also used for heart failure.[1]
Metabolism
It is metabolized by cytochrome P-450 2D6 allele and so may have drug interactions[2] and inherited variations in metabolism.[3]
Dosage
For healthy adults, the starting dose is 25 to 100 mg daily in single or divided doses and the maximum dose is 400 to 450 mg/day.
External links
The most up-to-date information about Metoprolol and other drugs can be found at the following sites.
- Metoprolol - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Metoprolol - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Metoprolol - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Metoprolol (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Onalan O, Cumurcu BE, Bekar L (May 2008). "Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine". Mayo Clin. Proc. 83 (5): 595–9. PMID 18452693. [e]
- ↑ Nozawa T, Taguchi M, Tahara K, et al (November 2005). "Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol". J. Cardiovasc. Pharmacol. 46 (5): 713–20. PMID 16220080. [e]