Gemfibrozil: Difference between revisions
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'''Gemfibrozil''', or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is | '''Gemfibrozil''', or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is a [[Antilipemic agent|antilipemic]] [[medication]] that lowers serum [[triglyceride]] levels, with variable effects on [[cholesterol]]. Gemfibrozil is a [[fibrate]] derivative similar to [[bezafibrate]], [[clofibrate]], and [[procetofen]] (fenofibrate). | ||
Gemfibrozil lowers the [[VLDL]] fraction more than it lowers the LDL fraction. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic [[lipoprotein lipase]]. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. Gemfibrozil can treat [[hypoalphalipoproteinemia]] by increasing the HDL subfractions HDL2 and HDL3, and [[apolipoprotein]]s A-I and A-II. It is supplemental therapy for type IIb [[hypercholesterolemia]]. | |||
== Drug Interactions == | == Drug Interactions == | ||
Gemfibrozil increases the anticoagulant effects of [[anisindione]], [[dicumarol]], [[acenocoumarol]] and [[warfarin]]. There is an increased risk of [[myopathy]]/[[rhaddomyolysis]] when gemfibrizol is taken with the cholesterol lowering statin drugs [[atorvastatin]] (Lipitor), [[cerivastatin]], [[fluvastatin]], [[lovastatin]], [[pravastatin]], and [[simvastatin]]. Gemfibrizol increases the effects and toxicity of [[pioglitazone]], [[rosiglitazone]] and [[repaglinide]]. The statin [[rosuvastatin]] may increase the effect of gemfibrizol, and gemfibrizol decreases the effects of [[ursodiol]]. | Gemfibrozil increases the [[anticoagulant]] effects of [[anisindione]], [[dicumarol]], [[acenocoumarol]] and [[warfarin]]. There is an increased risk of [[myopathy]]/[[rhaddomyolysis]] when gemfibrizol is taken with the cholesterol lowering statin drugs [[atorvastatin]] (Lipitor), [[cerivastatin]], [[fluvastatin]] (Lescol), [[lovastatin]], [[pravastatin]] (Pravachol), and [[simvastatin]] (Vytorin). Gemfibrizol increases the effects and toxicity of [[pioglitazone]], [[rosiglitazone]] and [[repaglinide]]. The statin [[rosuvastatin]] (Crestor) may increase the effect of gemfibrizol, and gemfibrizol decreases the effects of [[ursodiol]]. | ||
== Brand Names == | == Brand Names == | ||
<div class= style="-moz-column-count:3; column-count:3;"> | |||
*Apo-Gemfibrozil | *Apo-Gemfibrozil | ||
*Bolutol | *Bolutol | ||
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*Novo-Gemfibrozil | *Novo-Gemfibrozil | ||
*Nu-Gemfibrozil | *Nu-Gemfibrozil | ||
</div> | |||
== External Links == | == External Links == | ||
{{CZMed}} | |||
Latest revision as of 09:09, 3 November 2009
Gemfibrozil, or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is a antilipemic medication that lowers serum triglyceride levels, with variable effects on cholesterol. Gemfibrozil is a fibrate derivative similar to bezafibrate, clofibrate, and procetofen (fenofibrate).
Gemfibrozil lowers the VLDL fraction more than it lowers the LDL fraction. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic lipoprotein lipase. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. Gemfibrozil can treat hypoalphalipoproteinemia by increasing the HDL subfractions HDL2 and HDL3, and apolipoproteins A-I and A-II. It is supplemental therapy for type IIb hypercholesterolemia.
Drug Interactions
Gemfibrozil increases the anticoagulant effects of anisindione, dicumarol, acenocoumarol and warfarin. There is an increased risk of myopathy/rhaddomyolysis when gemfibrizol is taken with the cholesterol lowering statin drugs atorvastatin (Lipitor), cerivastatin, fluvastatin (Lescol), lovastatin, pravastatin (Pravachol), and simvastatin (Vytorin). Gemfibrizol increases the effects and toxicity of pioglitazone, rosiglitazone and repaglinide. The statin rosuvastatin (Crestor) may increase the effect of gemfibrizol, and gemfibrizol decreases the effects of ursodiol.
Brand Names
- Apo-Gemfibrozil
- Bolutol
- Cholespid
- Decrelip
- Fibratol
- Fibrocit
- Gemfibril
- Gemfibromax
- Gemlipid
- Gen-Fibro
- Genlip
- Gevilon
- Hipolixan
- Jezil
- Lipozid
- Lipur
- Lopid
- Novo-Gemfibrozil
- Nu-Gemfibrozil
External Links
The most up-to-date information about Gemfibrozil and other drugs can be found at the following sites.
- Gemfibrozil - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Gemfibrozil - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Gemfibrozil - Detailed information from DrugBank.