File:Cell signalling pathways related to stress in the endoplasmatic reticulum.png

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Summary

Title / Description


A schematic presentation of the three branches of the unfolded protein response, their signaling pathways, and pathological responses with respect to inflammation and Alzheimer's disease pathology.
Author(s)


Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J
Copyright holder


Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J
See below for license/re-use information.
Source


Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J (2009). "ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology". J Neuroinflammation 6: 41. DOI:10.1186/1742-2094-6-41. PMID 20035627. PMC PMC2806266. Research Blogging. [e]
Based on previous evidence indicating that "the unfolded protein response is activated in neurons but not in glial cells in AD brains, this paper describes "mechanisms which could link the ER stress of neurons to the activation of the inflammatory response and the evolution of pathological changes in AD."
Date created


December 2, 2009
Country of first publication


United States
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