Tumor necrosis factor-alpha

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In medicine, tumor necrosis factor-alpha is a "serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to tnf-beta (lymphotoxin), but they share TNF receptors.[1]

Tumor necrosis factor inhibitors

  • TNFR-Fc fusion protein (etanercept - pronounced et a ner' set) blocks the activity of TNF-alpha.[2]
  • Infliximab is a chimeric monoclonal antibody that blocks the action of TNF-alpha by binding to it.[3]

References

  1. ↑ Anonymous (2024), Tumor necrosis factor-alpha (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Template:MedMaster
  3. ↑ Template:MedMaster
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