Head and neck cancer: Difference between revisions
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'''Head and neck cancer''' includes "Soft tissue tumors or cancer arising from the mucosal surfaces of the [[lip]]; oral cavity; [[pharynx]]; [[larynx]]; and cervical [[esophagus]]. Other sites included are the [[nose]] and [[paranasal sinuses]]; [[salivary glands]]; [[thyroid gland]] and [[parathyroid glands]] and [[melanoma]]and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)<ref>{{<MeSH>}}</ref> | |||
==Cause / etiology== | ==Cause / etiology== | ||
===By location=== | |||
====Oropharynx==== | |||
[[Human papillomavirus]] (HPV) is a risk factor for oropharyngeal cancer.<ref name="pmid18784104">{{cite journal| author=Haddad RI, Shin DM| title=Recent advances in head and neck cancer. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 11 | pages= 1143-54 | pmid=18784104 | [[Human papillomavirus]] (HPV) is a risk factor for oropharyngeal cancer.<ref name="pmid18784104">{{cite journal| author=Haddad RI, Shin DM| title=Recent advances in head and neck cancer. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 11 | pages= 1143-54 | pmid=18784104 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=18784104 | doi=10.1056/NEJMra0707975 }} </ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=18784104 | doi=10.1056/NEJMra0707975 }} </ref> | ||
====Lip==== | |||
Pipe and cigar smoking are risk factors. | |||
====By histological type==== | |||
==Treatment== | ==Treatment== | ||
{{PDQ-treatment|http://www.cancer.gov/cancertopics/types/head-and-neck|Head and Neck Cancer}} | {{PDQ-treatment|http://www.cancer.gov/cancertopics/types/head-and-neck|Head and Neck Cancer}} | ||
{{PDQ-treatment|http://www.cancer.gov/cancertopics/pdq/treatment/salivarygland/HealthProfessional/page5|Salivary Gland Cancer}} | {{PDQ-treatment|http://www.cancer.gov/cancertopics/pdq/treatment/salivarygland/HealthProfessional/page5|Salivary Gland Cancer}} | ||
===By location=== | |||
=== | ===By histologic type==== | ||
====Carcinoma==== | |||
[[Cetuximab]] chimeric recombinant monoclonal [[antibody]] that blocks [[epidermal growth factor receptor]] (EGFR).<ref name="pmid18784104">{{cite journal| author=Haddad RI, Shin DM| title=Recent advances in head and neck cancer. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 11 | pages= 1143-54 | pmid=18784104 | [[Cetuximab]] chimeric recombinant monoclonal [[antibody]] that blocks [[epidermal growth factor receptor]] (EGFR).<ref name="pmid18784104">{{cite journal| author=Haddad RI, Shin DM| title=Recent advances in head and neck cancer. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 11 | pages= 1143-54 | pmid=18784104 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=18784104 | doi=10.1056/NEJMra0707975 }} </ref>In the major [[randomized controlled trial]], the percentage of cells that are EGFR positive did not seen to predict the response to cetuximab.<ref name="pmid18784101">{{cite journal| author=Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S et al.| title=Platinum-based chemotherapy plus cetuximab in head and neck cancer. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 11 | pages= 1116-27 | pmid=18784101 | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=18784104 | doi=10.1056/NEJMra0707975 }} </ref>In the major [[randomized controlled trial]], the percentage of cells that are EGFR positive did not seen to predict the response to cetuximab.<ref name="pmid18784101">{{cite journal| author=Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S et al.| title=Platinum-based chemotherapy plus cetuximab in head and neck cancer. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 11 | pages= 1116-27 | pmid=18784101 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=18784101 | doi=10.1056/NEJMoa0802656 }} </ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=18784101 | doi=10.1056/NEJMoa0802656 }} </ref> | ||
[[Radiotherapy]] is the first-line palliative treatment for [[feline squamous cell carcinoma]], with adjuvant therapy with [[NSAID]]s such as [[piroxicam]] and [[meloxicam]], as well as experimental protocols using adjuvant [[hyperthermia]] and [[hyperbaric oxygen]]. [[Bleomycin]] and [[carboplatin]] are the core of chemotherapy. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 13:39, 31 May 2010
Head and neck cancer includes "Soft tissue tumors or cancer arising from the mucosal surfaces of the lip; oral cavity; pharynx; larynx; and cervical esophagus. Other sites included are the nose and paranasal sinuses; salivary glands; thyroid gland and parathyroid glands and melanomaand non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)[1]
Cause / etiology
By location
Oropharynx
Human papillomavirus (HPV) is a risk factor for oropharyngeal cancer.[2]
Lip
Pipe and cigar smoking are risk factors.
By histological type
Treatment
Head and Neck Cancer treatment information from the National Cancer Institute's Physician Data Query
Salivary Gland Cancer treatment information from the National Cancer Institute's Physician Data Query
By location
By histologic type=
Carcinoma
Cetuximab chimeric recombinant monoclonal antibody that blocks epidermal growth factor receptor (EGFR).[2]In the major randomized controlled trial, the percentage of cells that are EGFR positive did not seen to predict the response to cetuximab.[3]
Radiotherapy is the first-line palliative treatment for feline squamous cell carcinoma, with adjuvant therapy with NSAIDs such as piroxicam and meloxicam, as well as experimental protocols using adjuvant hyperthermia and hyperbaric oxygen. Bleomycin and carboplatin are the core of chemotherapy.
References
- ↑ {{<MeSH>}}
- ↑ 2.0 2.1 Haddad RI, Shin DM (2008). "Recent advances in head and neck cancer.". N Engl J Med 359 (11): 1143-54. DOI:10.1056/NEJMra0707975. PMID 18784104. Research Blogging.
- ↑ Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S et al. (2008). "Platinum-based chemotherapy plus cetuximab in head and neck cancer.". N Engl J Med 359 (11): 1116-27. DOI:10.1056/NEJMoa0802656. PMID 18784101. Research Blogging.