Epidermal growth factor receptor

From Citizendium
Jump to navigation Jump to search
This article is a stub and thus not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.

In biochemistry, epidermal growth factor receptor 2 (EGFR, erbB-1, HER1, HER-1) is a cell surface receptor that is a "involved in regulation of cell growth and differentiation. It is specific for epidermal growth factor and EGF related peptides including transforming growth factor alpha, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell."[1]

Cetuximab (IMC-C225) is a recombinant, human/mouse chimeric monoclonal antibody that binds to EGFR and may treat head and neck cancers, colorectal cancer, and non-small cell lung cancer in patients who do not have mutations in the KRAS gene.[2] Panitumumab is also a monoclonal antibody that binds to EGFR and may treat colorectal cancer.

References

  1. Anonymous (2023), Epidermal growth factor receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A et al. (2009). "Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.". N Engl J Med 360 (14): 1408-17. DOI:10.1056/NEJMoa0805019. PMID 19339720. Research Blogging.