Venous stasis ulcer
In medicine, venous stasis ulcers (varicose ulcer) are a form of leg ulcer due to venous insufficiency and are "skin breakdown or ulceration caused by varicose veins in which there is too much hydrostatic pressure in the superficial venous system of the leg. Venous hypertension leads to increased pressure in the capillary bed, transudation of fluid and proteins into the interstitial space, altering blood flow and supply of nutrients to the skin and subcutaneous tissues, and eventual ulceration."
The most likely cause is lost efficiency of the valves in the deep veins of the leg increasing the pressure in the veins and thus decreasing the exchange of blood from arteries through the capillaries. It is not clear how often this is due to primary incompetence of the deep and/or perforating venous valves versus deep venous thrombosis.
Compression bandages improve healing. Non-elastic, ambulatory, below knee (BK) compression counters the impact of reflux on venous pump failure. Compression therapy is used for venous leg ulcers and can decrease blood vessel diameter and pressure, which increases their effectiveness, preventing blood from flowing backwards. Compression is also used  to increase release of inflammatory cytokines, lower the amount of fluid leaking from capillaries and therefore prevent swelling, and prevent clotting by decreasing activation of thrombin and increasing that of plasmin.
It is not clear whether non-elastic systems are better than a multilayer elastic system. Compression is applied using elastic bandages or boots specifically designed for the purpose. Patients should wear as much compression as is comfortable. 
Intermittent pneumatic compression devices may be used, but it is not clear that they are superior to simple compression dressings.
Type of dressing
Regarding types of high pressure bandages, (ankle pressure 35-40 mm Hg), an individual patient data meta-analysis concluded "four layer bandages heal faster, on average, than those of people treated with the short stretch bandage." High pressure dressing are contraindicated in patients with significant peripheral arterial disease.
The type of dressing applied beneath the compression may or may not matter. A meta-analysis by the Cochrane Collaboration concluded the type of dressing does note matter, specially hydrogel and hydocolloid are not better than simple low adherent dressings. Another systematic review concluded that hydocolloid is better. The optimal pressure for treating venous stasis ulcers according to one trial is below; in this trial the average ulcer size was 10 cm2 (diameter = 3 cm) and the average calf circumference was 40 cm:
A meta-analysis of randomized controlled trials by the Cochrane Collaboration found that "Pentoxifylline is an effective adjunct to compression bandaging for treating venous leg ulcers and may be effective in the absence of compression".
Artificial skin, made of collagen and cultured skin cells, is also used to cover venous ulcers and excrete growth factors to help them heal. A meta-analysis of randomized controlled trials by the Cochrane Collaboration concluded "Bilayer artificial skin, used in conjunction with compression bandaging, increases the chance of healing a venous ulcer compared with compression and a simple dressing".
Surgical correction of superficial venous reflux
Antibiotics and antiseptics
Among antibiotics and antiseptics, cadexomer iodine (Iodosorb™) may increase healing rates.
Iloprost, a synthetic analogue of prostacyclin PGI2 can improve healing according to a randomized controlled trial. In this initial trial, healing rates at 90 days were 100% in the intervention group and 50% in the control group.
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