Talk:Lipostatic hypothesis

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 Definition The theory that the hypothalamic satiety mechanisms are sensitive to the concentration of circulating metabolites. [d] [e]
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Lucy Thornton Jones 14:41, 25 September 2011 (UTC)

Sophie Rajska 10:50, 10 October 2011 (UTC) Charles James Vaillant Foster 14:14, 11 October 2011 (UTC)

Hi guys, you might want to improve your reference list pretty quickly, make sure you enter them in the Bibliography page, and also make sure to pick references from scientific, peer-reviewed journals. Sophie and Lucy, I can see you did some article seach, which is good, but some of your references do not belong to such journals, or have a defective link. Also, please enter the ref with authors'names, title, journal, date, etc, plus a short summary of the article, as shown in the following example [1]

Maybe Charles and Mathilda could give their input and help the group? Nancy Sabatier 15:26, 12 October 2011 (UTC)

Yes, this task is about some really important basic skills - systematic searching, critical selection, rigorous citation and crisp, concise summaries. These skills are the key to acquiring knowledge in depth and breadth, so don't take it lightly.Gareth Leng 20:03, 12 October 2011 (UTC)

I've edited the description of the parabiosis experiments - it's important to keep in mind that these were performed before any knowledge of leptin.

Depth -You need to go deeper than this in your reading, and be very careful of details. For example (and I've edited your text to correct this) the POMC cells are in the arcuate nucleus (not the VMN), and they project to the PVN - the PVN does not contain POMC cells. The arcuate neurones are the primary target of leptin. Don't write casually in a way that doesn't make this clear. The ob/ob mouse is technically not a knockout mouse - it wasn't a transgenic mouse, but an inbred strain. You've talked about leptin but what about other products of adipocytes? You haven't gone beyond 3rd year level here. Leptin crosses the blood brain barrier, but how it does so is far from clear - it seems likely that it's actively transported in at the choroid plexus, but might access directly at the arcuate nucleus. What other relevant targets are there?

Breadth need to put this in a broader context - can do this in any of many ways - what pathways are downstream of leptin's actions? How does this hypotheseis dirffer from/relate to other hypotheses??Gareth Leng 17:57, 8 November 2011 (UTC)