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Posterior leukoencephalopathy syndrome

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In neurology, posterior leukoencephalopathy syndrome (also called posterior reversible encephalopathy syndrome, PRES) is "a condition that is characterized by headache; seizures; and visual loss with edema in the posterior aspects of the cerebral hemispheres, such as the brain stem. Generally, lesions involve the white matter (nerve fibers) but occasionally the grey matter (nerve cell bodies)."[1]

It "...may develop in patients who have renal insufficiency or hypertension or who are immunosuppressed. The findings on neuroimaging are characteristic of subcortical edema without infarction." [2]

PRES may manifest as a transient neurological attack. PRES is similar to reversible cerebral vasoconstriction syndrome (RCVS) .


  1. Anonymous (2021), Posterior leukoencephalopathy syndrome (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A et al. (1996). "A reversible posterior leukoencephalopathy syndrome.". N Engl J Med 334 (8): 494-500. PMID 8559202.