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Mirtazapine is a second-generation antidepressant agent. Mirtazapine is also classified as a tricyclic antidepressant by the National Library of Medicine in the United States of America.[1]


Remeron brand of mirtazapine was approved for Organon USA by the Food and Drug Administration in the United States of America with a New Drug Application (NDA) in 1996.[2] A generic version with a AB Therapeutic Equivalence Code was approved for Glenmark Generics with a Abbreviated New Drug Application (ANDA) in 2004.[3]


"The clinical response of our patients underscores the usefulness of mirtazapine in the treatment of the comorbid symptoms of weight loss, insomnia, and anxiety". [4]


Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA).[5]






Drug toxicity is similar to tricyclic antidepressants. Amitriptyline, mirtazapine, and paroxetine may case more weight gain than other antidepressants according to a meta-analysis.[6]

Compared to other antidepressants, a second meta-analysis found that mirtazapine was "more likely to cause weight gain or increased appetite and somnolence than SSRIs but less likely to cause nausea or vomiting and sexual dysfunction."[5]

Mirtazapine can cause elevated liver function tests and neutropenia[7]

External links

The most up-to-date information about Mirtazapine and other drugs can be found at the following sites.


  1. Anonymous (2023), Mirtazapine (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Anonymous. Drugs@FDA for FDA Application No. 020415. U S Food and Drug Administration
  3. Anonymous. Drugs@FDA for FDA Application No. 076119. U S Food and Drug Administration
  4. Raji MA, Brady SR (2001). "Mirtazapine for treatment of depression and comorbidities in Alzheimer disease.". Ann Pharmacother 35 (9): 1024-7. PMID 11573849[e]
  5. 5.0 5.1 Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R et al. (2011). "Mirtazapine versus other antidepressive agents for depression.". Cochrane Database Syst Rev 12: CD006528. DOI:10.1002/14651858.CD006528.pub2. PMID 22161405. Research Blogging.
  6. Serretti A, Mandelli L (2010). "Antidepressants and body weight: a comprehensive review and meta-analysis.". J Clin Psychiatry 71 (10): 1259-72. DOI:10.4088/JCP.09r05346blu. PMID 21062615. Research Blogging.
  7. Montgomery SA (1995). "Safety of mirtazapine: a review.". Int Clin Psychopharmacol 10 Suppl 4: 37-45. PMID 8930008[e]