Methylenetetrahydrofolate reductase

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In biochemistry, methylenetetrahydrofolate reductase is a "flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate."[1]

Deficient activity of methylenetetrahydrofolate reductase is associated with elevated levels of homocysteine and coronary heart disease.[2]


  1. Anonymous (2021), Methylenetetrahydrofolate reductase (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Wald DS, Wald NJ, Morris JK, Law M (November 2006). "Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence". BMJ 333 (7578): 1114–7. DOI:10.1136/bmj.39000.486701.68. PMID 17124224. PMC 1661741. Research Blogging.