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- Ancient Greece : The loose collection of Greek-speaking city-states centered on the Aegean Sea which flourished from the end of the Mycenaean age to the Roman conquest of Greece in 146 BC.
- Biology : The science of life — of complex, self-organizing, information-processing systems living in the past, present or future.
- Discourse on Method : Philosophical and mathematical treatise published by René Descartes in 1637, best known as the source of the famous quotation 'Je pense, donc je suis' ('I think, therefore I am').
- Euclid : (ca. 325 BC - ca. 265 BC) Alexandrian mathematician and known as the father of geometry.
- Immanuel Kant : (1724–1804) German idealist and Enlightenment philosopher who tried to transcend empiricism and rationalism in the Critique of Pure Reason.
- Johannes Kepler : (1571-1630) German astronomer best known for his three laws of planetary motion.
- Ptolemy : (2nd century AD) Egyptian astronomer and geographer whose main work, the Almagest, a compendium of contemporary astronomical knowledge, was in use into the 15th century.
- Reformation : The major religious revolution in Western Europe in the 16th century, led by Martin Luther, John Calvin and other Protestants.
- Renaissance : Cultural movement that spanned roughly the 14th to the 17th century, beginning in Florence in the Late Middle Ages and later spreading to the rest of Europe.
- René Descartes : French 17th-century philosopher, mathematician and scientist, author of the Discourse on Method.
- Scientific method : The concept of systematic inquiry based on hypotheses and their testing in light of empirical evidence.