Citizendium - a community developing a quality, comprehensive compendium of knowledge, online and free.
Click here to join and contribute
CZ thanks our previous donors. Donate here. Treasurer's Financial Report

Histamine H2 antagonist

From Citizendium
Jump to: navigation, search
This article is developing and not approved.
Main Article
Definition [?]
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
This editable Main Article is under development and subject to a disclaimer.

In medicine, histamine H2 antagonists are "drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood."[1]

Clinically, therapy with H2 antagonists is usually complemented by proton pump inhibitors. They may also be synergistic with histamine H1 antagonists.


  1. Anonymous (2020), Histamine H2 antagonist (English). Medical Subject Headings. U.S. National Library of Medicine.