It started with two strips. The first was called "Ms Lonelyhearts" and progressively disappeared. The second featured Irene van de Kamp, a heiress who grew up in Africa and who has face markings and a circular plate in her lower lip. She meets an assortment of weird characters while trying to find romance and avoid people who are only after her money. The sixth issue contained letters by Scott McCloud and Peter Bagge.
A collection of the strips called Goodnight, Irene was published in June 2007 by Last Gasp.