BRCA2 gene

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In physiology, BRCA2 gene (BRCA-2 gene) is "a tumor suppressor gene located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."[1]

Women who have BRCA1 or BRCA2 genes, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]

References

  1. Anonymous (2021), BRCA2 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637