BRCA2 gene

From Citizendium
Jump to: navigation, search
This article is a stub and thus not approved.
Main Article
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
This editable Main Article is under development and subject to a disclaimer.

In physiology, BRCA2 gene (BRCA-2 gene) is "a tumor suppressor gene located on human chromosome 13 at locus 13q12.3. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements."[1]

Women who have BRCA1 or BRCA2 genes, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]


  1. Anonymous (2021), BRCA2 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637