Penciclovir/Related Articles: Difference between revisions

Latest revision as of 12:35, 28 March 2009

Citable Version ^[?]

A list of Citizendium articles, and planned articles, about Penciclovir.

See also changes related to Penciclovir, or pages that link to Penciclovir or to this page or whose text contains "Penciclovir".

Antiviral drug [r]: A chemical that interfers with the replication cycle of viruses. ^[e]
Nucleotide analogue [r]: Add brief definition or description
Herpesvirus [r]: Add brief definition or description
Herpes simplex virus [r]: One of the herpes, DNA viruses that are important in causing human disease. ^[e]
Famciclovir [r]: Antiviral drug used for the treatment of herpes viruses, especially herpes zoster (shingles). ^[e]

DNA synthesis [r]: Please do not use this term in your topic list, because there is no single article for it. Please substitute a more precise term. See DNA synthesis (disambiguation) for a list of available, more precise, topics. Please add a new usage if needed.
Acyclovir [r]: An antiviral, anti-metabolite drug, similar to guanine, that acts as a viral DNA chain terminator. ^[e]

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-'''Penciclovir''' ('''PE2''') or '''penciclovirum''', is a [[guanosine]] analog, [[antiviral drug]] used to treat [[herpesvirus]]es and is the active metabolite of the prodrug [[famciclovir]].  It is sold under the brand name '''Denavir®'''.  The longer [[half-life]] of penciclovir triphosphate in herpes-infected cells (10-20 hrs), compared to that of [[acyclovir]] (0,7 -1 hr), may be responsible for its ehanced results.
-The triphosphate form competes with [[deoxyguanosine]] triphosphate for incorporation into viral DNA.  It only effects DNA synthesis of only those cells infected with [[herpes simplex virus]] (HSV).
 ==Parent topics==