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Penciclovir structure.jpg
IUPAC name: see chemistry
Synonyms: Denavir®, PE2, penciclovirum
Formula: C10H15N5O3

 Uses: herpes viruses

 Properties: guanosine analog

 Hazards: see drug interactions

Mass (g/mol): CAS #:
253.2578 84625-61-6

Penciclovir (PE2) or penciclovirum, is a guanosine analog, antiviral drug used to treat herpesviruses and is the active metabolite of the prodrug famciclovir. It is sold under the brand name Denavir®. The longer half-life of penciclovir triphosphate in herpes-infected cells (10-20 hrs), compared to that of acyclovir (0,7 -1 hr), may be responsible for its ehanced results. The triphosphate form competes with deoxyguanosine triphosphate for incorporation into viral DNA. It only effects DNA synthesis of only those cells infected with herpes simplex virus (HSV).


The IUPAC chemical name of penciclovir is 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one, and it has chemical formula C10H15N5O3, giving it a molecular mass of 253.2578 g/mol. It is an analog of the natural nucleotide guanosine. The prodrug famciclovir is an analog of this drug.

External links

The most up-to-date information about Penciclovir and other drugs can be found at the following sites.