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IUPAC name: see chemistry section
Synonyms: VCZ
Formula: C16H14F3N5O

 Uses: antifungal drug

 Properties: azole compound

 Hazards: see side effects & drug interactions

Mass (g/mol): CAS #:
349.3105 137234-62-9

Voriconazole, sold under the brand name Vfend®, is a triazole-based antifungal drug used to treat infections due to fungi, usually to treat invasive infection in immunocompromised patients or fluconazole-resistant strains. It is used to treat candidiasis, apergillosis, Scedosporium apiospermum and Fusarium species including Fusarium solani.

Mechanism of action

Azole-based antifungal agents, such as voriconazole, inhibit the cytochrome P450 enzyme 14-alpha-demethylase, and by doing so stop the conversion of lanosterol to ergosterol, an important component of fungal cell wall membranes. The lack of ergosterol makes the fungal cell wall permeable and inhibits cell growth.


The IUPAC name of voriconazole is (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan- 2-ol and its molecular formula, C16H14F3N5O, gives it a molecular mass of 349.3105 g/mol. The activity of the drug is based on the presence of an azole.

References & external links

The most up-to-date information about Voriconazole and other drugs can be found at the following sites.