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Fluconazole
From Citizendium, the Citizens' Compendium
Fluconazole.
Fluconazole, IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat oropharyngeal (vaginal) candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with the enzyme 14-α demethylase that converts lanosterol to ergosterol. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage.
Brand Names
- Biocanol®
- Biozolene®
- Diflucan®
- Elazor®
- Flucazol®
- Flucostat®
- Flukezol®
- Flunizol®
- Flusol®
- Pritenzol®
- Triflucan®
External Links
- Fluconazole - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Fluconazole - Drug information for patients from MedMaster (U.S. National Library of Medicine).
- Fluconazole - Detailed information from DrugBank.
