Tipranavir

From Citizendium, the Citizens' Compendium

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tipranavir
IUPAC name: see chemistry section Synonyms: Aptivus® Formula: C31H33F3N2O5S
Uses:	HIV
Properties:	protease inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 602.6643 174484-41-4

Tipranavir (TPV), sold under the brand name Aptivus®, is a nonpeptidic protease inhibitor drug used to treat HIV/AIDS in combination with ritonavir. It is used for patients with extensive previous treatment of those infected with HIV strains that have multiple protease inhibitor resistance. Tipranavir blocks the function of protease enzymes sothat the Gag and Gag-Pol polyprotein cannot be cleaved into individual active proteins, thus blocking the formation of infectious mature viral particles. Such inhibitors all almost always used in a combination therapy with other anti-HIV drugs.

Chemistry

Its IUPAC chemical name is Name N-[3-[(1R)-1-[(6R)-2-hydroxy-4-oxo-6-(2-phenylethyl)-6-propyl-5H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide and its chemical formula is C₃₁H₃₃F₃N₂O₅S.

External Links

The most up-to-date information about Tipranavir and other drugs can be found at the following sites.

• Tipranavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Tipranavir - Drug information for patients from MedMaster (U.S. National Library of Medicine).
• Tipranavir - Detailed information from DrugBank.