From Citizendium, the Citizens' Compendium
Jump to: navigation, search
This article is developing and not approved.
Main Article
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
This editable Main Article is under development and not meant to be cited; by editing it you can help to improve it towards a future approved, citable version. These unapproved articles are subject to a disclaimer.
(CC) Image: David E. Volk

Cinoxacin (Cinobac®) is an antibiotic drug use to treat urinary tract infections caused by many aerobic, Gram-negative bacteria. It is active against susceptible strains of E. coli, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumoniae, and Enterobacter species.

Mechanism of action

Cinoxacin binds to DNA and interferes with the synthesis of viral RNA and therefore inhibits the production of viral proteins.


Cinoxacin's IUPAC chemical name is 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid and its chemical formula is C12H10N2O5 (MW=262.2182 g/mol). It is related to oxolinic acid and nalidixic acid and it is active over the entire urinary pH range.

External links

The most up-to-date information about Cinoxacin and other drugs can be found at the following sites.