United Kingdom Prospective Diabetes Study

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In health care, the United Kingdom Prospective Diabetes Study (UKPDS) is a randomized controlled trial of the treatment of diabetes mellitus type 2.[1][2] Long term follow-up after 10 years is available.[3]

Trial design of the UKPDS 33.
Trial design of the UKPDS 34.

The UKPDS has created a clinical prediction rule.[4][5]

The study's website is at http://www.dtu.ox.ac.uk/ukpds_trial/.

References

  1. ↑ (1998) "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group". Lancet 352 (9131): 837–53. DOI:10.1016/S0140-6736(98)07019-6. PMID 9742976. Research Blogging. Review by ACP Journal Club
  2. ↑ (1998) "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.". Lancet 352 (9131): 854-65. PMID 9742977.
  3. ↑ Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008). "10-year follow-up of intensive glucose control in type 2 diabetes.". N Engl J Med 359 (15): 1577-89. DOI:10.1056/NEJMoa0806470. PMID 18784090. Research Blogging. Review in: ACP J Club. 2008 Dec 16;149(6):4 Review in: Evid Based Nurs. 2009 Jan;12(1):14 Review in: Evid Based Med. 2009 Feb;14(1):9-10
  4. ↑ Stevens RJ, Kothari V, Adler AI, Stratton IM, United Kingdom Prospective Diabetes Study (UKPDS) Group (2001). "The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56).". Clin Sci (Lond) 101 (6): 671-9. PMID 11724655. [e]
  5. ↑ UKPDS Risk Engine
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