Anticonvulsant: Difference between revisions
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In [[medicine]], '''anticonvulsants''' are [[medication]]s "used to prevent [[seizure]]s or reduce their severity."<ref>{{MeSH}}</ref> | In [[medicine]], '''anticonvulsants''' are [[medication]]s "used to prevent [[seizure]]s or reduce their severity."<ref>{{MeSH}}</ref> A number of the drugs have additional applications in [[pain management]] or in [[psychiatry]]. | ||
== | ==Pharmacologic classes== | ||
{{ | There are three main mechanisms of action:<ref name=GG>{{citation | ||
| contribution = Chapter 20, Drugs Effective in the Therapy of the Epilepsies | |||
| author = James O. McNamara | |||
| title = Goodman and Gilman's The Pharmacological Basis of Therapeutics | |||
| edition = Ninth Edition | |||
| year = 1996 | |||
| editor = JG Hardman ''et al.'' | |||
| publisher = McGraw-Hill}}, p. 461</ref> | |||
#Limiting the sustained firing of neurons, by promoting the inactive state of voltage-gated sodium channels | |||
#Enhanicing the effectiveness of [[gamma-aminobutyric acid]] (GABA) mediation of synaptic inhibition | |||
#Limiting action of a specific voltage-gated calcium channel | |||
==Adverse effects== | ==Adverse effects== | ||
| Line 22: | Line 32: | ||
==References== | ==References== | ||
{{reflist|2}} | |||
Latest revision as of 13:48, 12 June 2010
In medicine, anticonvulsants are medications "used to prevent seizures or reduce their severity."[1] A number of the drugs have additional applications in pain management or in psychiatry.
Pharmacologic classes
There are three main mechanisms of action:[2]
- Limiting the sustained firing of neurons, by promoting the inactive state of voltage-gated sodium channels
- Enhanicing the effectiveness of gamma-aminobutyric acid (GABA) mediation of synaptic inhibition
- Limiting action of a specific voltage-gated calcium channel
Adverse effects
Anticonvulsants may increase risk of suicide.[3]
References
- ↑ Anonymous (2024), Anticonvulsant (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ James O. McNamara (1996), Chapter 20, Drugs Effective in the Therapy of the Epilepsies, in JG Hardman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics (Ninth Edition ed.), McGraw-Hill, p. 461
- ↑ Patorno, Elisabetta; Rhonda L. Bohn, Peter M. Wahl, Jerry Avorn, Amanda R. Patrick, Jun Liu, Sebastian Schneeweiss (2010-04-14). "Anticonvulsant Medications and the Risk of Suicide, Attempted Suicide, or Violent Death". JAMA 303 (14): 1401-1409. DOI:10.1001/jama.2010.410. Retrieved on 2010-04-14. Research Blogging.