Gut-brain signalling/Bibliography
Primary Research Papers
- Dockray GJ. (2008) The versatility of the vagus. Physiology & Behaviour 97:531-536 (Afferent neurons of the vagus nerve provide an important pathway for gut signals that act by triggering ascending pathways from the brain stem to hypothalamus...satiety hormone cholecystokinin (CCK) not only stimulates the discharge of these neurons but also controls their expression of both G-protein coupled receptors and peptide neurotransmitters known to influence food intake)
Tsurugizawa T. et al. (2009) Mechanisms of neural response to gastrointestinal nutritive stimuli: The gut-brain axis. Gasroenterology 137:262-273 (The gut-brain axis, which transmits nutrient information from the gastrointestinal tract to the brain, is important for the detection of dietary nutrition)
Korbonits M. et al (2004) Ghrelin-a hormone with multiple functions neuroendocrinology 25:27-68 (Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities. It is mainly secreted from the stomach mucosa but it is also expressed widely in different tissues and therefore may have both endocrine and paracrine effects...Increasing data link ghrelin to the overall control of energy use and flow in situations where there is a limitation of energy sources and ghrelin appears to play a pivotal role in energy homeostasis)
Hameed S. et al (2009) Gut hormones and appetite control. Oral diseases 15:18-26 (There is now a substantial body of work in both rodent and human models demonstrating the effects of these peptides on appetite and work is underway to therapeutically manipulate the gut-brain axis for the treatment of obesity. In addition, it may also be possible to use our understanding of the entero-endocrine system to treat calorie-deficient states)