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For patients treated medically, methimazole is the first choice medication. [1] Methimazole 15 mg by mouth once per day will normalize the free T4 in 86% of patients with less liver toxicity than propylthiouracil.


  1. Nakamura H, Noh JY, Itoh K, Fukata S, Miyauchi A, Hamada N (2007). "Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by graves' disease". J. Clin. Endocrinol. Metab. 92 (6): 2157-62. DOI:10.1210/jc.2006-2135. PMID 17389704. PMID 17389704. Research Blogging.