Hydrophobic cluster analysis
Clusters of these hydrophobic amino acids are good markers of regular secondary structures and have been extensively used in the detection of similar folds or similar motifs between sequences showing very limited sequence relatedness.
- Gaboriaud C, Bissery V, Benchetrit T and Mornon JP (1987) Hydrophobic cluster analysis: an efficient new way to compare and analyse amino acid sequences. FEBS Lett. 224, 149-155
- Hennetin J, Tuan KL, Canard L, Colloc’h N, Mornon JP, Callebaut I (2003) Non-intertwined binary patterns of hydrophobic/nonhydrophobic amino acids are considerably better markers of regular secondary structures than nonconstrained patterns. Proteins 51, 236-244
- Callebaut I, Labess G, Durand P, Poupon A, Canard L, Chomilier J, Henrissat B, Mornon JP (1997) Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives. Cell Mol Life Sci 53, 621-645