Peptidyl-dipeptidase A
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Peptidyl-dipeptidase A is a "peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates".[1]
Peptidyl-dipeptidase A is also called Angiotensin I converting enzyme or Angiotensin converting enzyme converts angiotensin I to angiotensin II in the renin-angiotensin system.
Peptidyl-dipeptidase A is also called Kininase II because it inactivates bradykinin in the kallikrein-kinin system.
References
- ↑ Anonymous (2024), Peptidyl-dipeptidase A (English). Medical Subject Headings. U.S. National Library of Medicine.