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- ...ene are morbidly obese and this obesity can be reversed by giving the mice leptin. ...ses appetite by its effects on specific neurones in the brain that express leptin receptors; in particular on neurones of the [[arcuate nucleus]] and [[ventr6 KB (972 words) - 22:39, 17 September 2012
- 91 bytes (10 words) - 04:59, 20 May 2008
- * Sunter D ''et al.'' [http://www.neuroendo.org.uk/content/view/8/11/ Leptin: Your brain, appetite and obesity ]''Neuroendocrine Briefings''; British So193 bytes (25 words) - 08:21, 8 November 2010
- {{r|Leptin receptor}}222 bytes (26 words) - 17:06, 14 March 2009
Page text matches
- ...'et al.'' (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. ''Nature'' 393:72-6</ref> {{Image|leptin.jpeg|right|250px|The interaction of Leptin, CART and NPY}}1 KB (195 words) - 10:44, 21 September 2013
- * Sunter D ''et al.'' [http://www.neuroendo.org.uk/content/view/8/11/ Leptin: Your brain, appetite and obesity ]''Neuroendocrine Briefings''; British So193 bytes (25 words) - 08:21, 8 November 2010
- Cowley M et al. (2001) Leptin activates anorexigenic POMC neurones through a neutral network in the arcua Zhang Y & Scarpace PJ (2006) The role of leptin in leptin resistance and obesity "Physiol Behav" 88:249-256.1 KB (166 words) - 10:21, 1 December 2013
- ...ene are morbidly obese and this obesity can be reversed by giving the mice leptin. ...ses appetite by its effects on specific neurones in the brain that express leptin receptors; in particular on neurones of the [[arcuate nucleus]] and [[ventr6 KB (972 words) - 22:39, 17 September 2012
- ...by feedback from [[adipocyte|adipose tissue]] - including by the hormone [[leptin]]. Appetite is also subject to sensory stimuli - the sight and smell of [[F {{r|leptin}}1 KB (161 words) - 08:11, 18 July 2011
- ...of the body fat depot, was coded for by the ''ob'' gene and is known as [[leptin]].<ref>Zhang Y ''et al.'' (1994) Positional cloning of the mouse obese gene == What is leptin? ==8 KB (1,203 words) - 20:25, 16 September 2020
- {{r|Leptin}}285 bytes (34 words) - 04:58, 2 May 2009
- {{r|Leptin receptor}}222 bytes (26 words) - 17:06, 14 March 2009
- {{r|leptin}}187 bytes (22 words) - 04:57, 6 January 2011
- {{r|Leptin}}347 bytes (51 words) - 05:02, 20 May 2008
- {{r|leptin}}543 bytes (72 words) - 18:05, 6 November 2010
- {{r|Leptin}}560 bytes (75 words) - 11:07, 10 October 2010
- {{r|leptin}}616 bytes (81 words) - 18:17, 6 November 2010
- {{r|leptin}}603 bytes (80 words) - 18:18, 6 November 2010
- {{r|Leptin}}599 bytes (77 words) - 04:20, 22 July 2011
- {{r|leptin}}564 bytes (75 words) - 05:19, 19 July 2011
- {{r|Leptin}}663 bytes (87 words) - 12:09, 19 August 2012
- {{r|leptin}}780 bytes (102 words) - 10:38, 1 December 2013
- {{r|leptin}}629 bytes (82 words) - 05:17, 19 July 2011
- {{r|leptin}}759 bytes (98 words) - 10:49, 5 August 2011
- ==Leptin== *Cowley, MA. ''et al.''(2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate5 KB (702 words) - 17:23, 25 April 2013
- {{r|leptin}}800 bytes (112 words) - 09:25, 21 December 2010
- {{r|Leptin}}911 bytes (117 words) - 09:49, 1 December 2013
- ...2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. ''Neuron'' 2006. 49:191-2035 KB (699 words) - 06:41, 22 January 2014
- ...to orlistat in relation to leptin, as, when using sibutramine, transfer of leptin into the brain is maintained or even increased during weight loss which doe4 KB (533 words) - 07:32, 18 October 2013
- ...nic activation of the endocannabinoid system is linked to obesity and that leptin and endocannabinoid pathways may interact. ...t diet, the CB1 null mice do not become obese or insensitive to insulin or leptin, as wild type mice may, even though they consumed as much food. This impli6 KB (997 words) - 19:31, 20 May 2009
- ...ine; for example, in 1994, an important new appetite-regulating hormone, [[leptin]] was identified as a peptide hormone secreted from [[adipose tissue]] (fat ...])<ref>Sunter D ''et al.'' [http://www.neuroendo.org.uk/content/view/8/11/ Leptin: Your brain, appetite and obesity ]''Neuroendocrine Briefings''; British So4 KB (595 words) - 08:21, 8 November 2010
- ...ep/wake schedule would lead to an increased daily range in the circulating leptin.. which by influencing food intake and energy balance could be implicated i ...t. '''Physiology & Behaviour 66(2): 329-335''' (“…''the central actions of leptin may mediate the inhibitory effects of obesity on the expression of food-ant7 KB (924 words) - 14:05, 24 October 2010
- Chapter 15 Food intake and leptin during pregnancy and lactation Original Research Article Hormonal induction of leptin resistance during pregnancy. Gratton et al, 20073 KB (336 words) - 05:47, 9 October 2010
- {{r|leptin}}1 KB (157 words) - 12:09, 19 August 2012
- ...ods. In this 60-minute presentation, he focuses on the role of the hormone leptin in regulating fat accumulation. He also discusses his studies of a human po1 KB (185 words) - 22:32, 5 July 2010
- ...tp://www.ajcn.org/cgi/content/abstract/85/4/1121 Body mass index and serum leptin concentration independently estimate percentage body fat in older adults.]1 KB (157 words) - 22:05, 12 September 2009
- {{r|Leptin}}1 KB (175 words) - 08:13, 8 November 2010
- {{r|leptin}}1 KB (186 words) - 18:16, 6 November 2010
- {{r|leptin}}1 KB (185 words) - 18:06, 6 November 2010
- ...Adiposity signals and food reward: expanding the CNS roles of insulin and leptin ''Am J Physiol'' 284:R882-92 Figlewicz DP, Benoit SC (2009) Insulin, leptin, and food reward: update ''Am J Physiol'' 296:R9-R194 KB (553 words) - 12:33, 19 August 2012
- ...europeptide Y]] (NPY) and [[agouti-related peptide]] (AgRP), and induced [[leptin]] resistance contribute to increased appetite, while other mechanisms assoc ===Development of leptin and insulin resistance during different reproductive states===14 KB (2,124 words) - 10:09, 24 July 2011
- ...respects it can be considered as a counterpart of the hormone [[leptin]]; leptin, a hormone produced by [[adipose tissue]], suppresses appetite (an anorexig ...''|title=The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic |journal=Diabetes |volume=51 |pages=3412�8 KB (1,105 words) - 04:16, 22 July 2011
- Cowley MA ''et al'' (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate ...S ''et al''. (2004) Rapid rewiring of arcuate nucleus feeding circuits by leptin. ''Science'' 304:110-5 PMID 15064421.9 KB (1,121 words) - 13:51, 14 November 2010
- ...ef>Farooqi IS, O’Rahilly S(2008) Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity. nature clinical practice ''End POMC expression in the arcuate nucleus is regulated by [[leptin]], a hormone secreted by adipose tissue. Both the [[opioid]] peptide [[B en10 KB (1,388 words) - 10:34, 24 July 2011
- ...ed from the large fat mass) but appear to be insensitive to leptin - this "leptin resistance" appears to be similar to the "insulin resistance" seen in type ...which lacks a blood-brain barrier, so it is also possible that ghrelin and leptin gain direct entry into the brain at this site.13 KB (1,944 words) - 10:25, 8 August 2011
- ...wakefulness. Hormones involved in appetite regulation such as ghrelin and leptin can influence these areas of the brain thus may have a role in resetting th ...(2001) The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels ''Endocrinology'' 142:2677–85</ref> and yet the role of the SCN in12 KB (1,822 words) - 23:48, 25 October 2013
- ...the dopamine reward pathways <ref>Figlewicz DP, Benoit SC (2009) Insulin, leptin, and food reward: update 2008 ''Am J Physiol'' 296:R9-19</ref> Receptors fo or inhibition e.g. by insulin or leptin of dopamine signalling to the nucleus accumbens <ref>Magni P ''et al.'' (2015 KB (2,139 words) - 12:15, 19 August 2012
- {{r|Leptin}}2 KB (295 words) - 10:18, 30 May 2009
- ...t for short-term appetite control, but newly discovered peptides such as [[leptin]] became more likely candidates for long-term control. ...feeding thus appears to involve other factors, such as the secretion of [[leptin]] from fat ([[adipocyte|adipose]]) tissue.6 KB (916 words) - 04:11, 17 April 2013
- ...leptin... is detectable in serum and that obese subjects have higherserum leptin concentrations than normal- weight subjects. The values were most closely r7 KB (990 words) - 07:54, 12 November 2011
- ...s]]es'' are structures specialised to import blood-borne factors such as [[leptin]] across the blood-brain barrier.<ref>Redzic ZB ''et al.'' (2005) The choro3 KB (389 words) - 09:41, 23 February 2009
- ...ly associated with the actions of two important regulators of food intake, leptin and neuropeptide"'' ...ly associated with the actions of two important regulators of food intake, leptin and neuropeptide Y''10 KB (1,390 words) - 07:46, 19 December 2010
- ...available. These neurons are regulated by circulating concentrations of [[leptin]] (a hormone secreted from fat cells ([[adipose tissue]]) and [[ghrelin]] ( ...a MSH. These neurons are also regulated by circulating concentrations of [[leptin]] and [[ghrelin]]. They are directly innervated by the NPY/AGRP neurons, wh8 KB (1,075 words) - 10:43, 5 August 2011
- ...peptide]] (AgRP), and these neurones are inhibited by leptin. Conversely, leptin excitates anorexigenic neurons that express [[pro-opiomelanocortin]] (POM ...is no direct effect of cortisol but it may influence other factors such as leptin, NPY or certain cytokines which have a more direct effect on eating. <ref>13 KB (2,018 words) - 10:16, 24 July 2011
- ...ted to monogenic causes. Many of these are mutations of proteins in the “[[leptin]] pathway” which has an important role in energy balance. Each of those r {{Image|Leptin_pathway2.png|centre|550px|Leptin pathway}}21 KB (3,145 words) - 15:26, 25 February 2023
- ...n the regulation of appetite. They are directly activated in response to [[leptin]], a hormone releasec from [[adipocyte]]s that circulates in concentrations4 KB (567 words) - 12:46, 6 January 2011
- ...besity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insul ==Leptin==31 KB (4,537 words) - 09:57, 18 February 2011
- ...taneous fat explains the association between insulin resistance and plasma leptin concentrations. ''Diabetes'' 51:1005-15</ref> ...ly caused by a deficiency in leptin; instead there seems to be a defect in leptin signalling. Adipocytes also produce an array of other peptides including [[22 KB (3,226 words) - 23:57, 24 February 2012
- ...appetite. There seems to be a correlation between AMPK and the hormones [[leptin]] and [[ghrelin]] which have opposite effects on energy uptake. While it is ...o observe the effects of AMPK in the hypothalamus. AMPK was decreased when leptin was injected, while ghrelin caused an increase in production. The effects w13 KB (2,140 words) - 10:29, 1 December 2013
- ...many peptide hormones secreted by peripheral endocrine tissues, such as [[leptin]], [[ghrelin]], [[angiotensin]] and [[insulin]]. Also pituitary hormones, [ ...creted from the [[stomach]]. These have important effects on [[appetite]]; leptin normally acts to suppress appetite, whereas ghrelin, which is secreted from16 KB (2,283 words) - 09:06, 15 March 2011
- *Increase in hormones such as leptin and insulin with weight gain ...o the extent that leptin may increase blood pressure, then the increase in leptin with subcutaneous fat cells (particularly when they become enlarged) could22 KB (3,243 words) - 08:33, 17 April 2024
- ...that is a potent stimulator of hunger. Conversely, they are inhibited by [[leptin]], a hormone secreted by [[adipocyte]]s in proportion to total body fat mas4 KB (592 words) - 06:39, 6 January 2011
- ...energy intake is used – i.e. how fat we get<ref>Ahima RS ''et al.'' (2000) Leptin regulation of neuroendocrine systems ''Front Neuroendocrinol'' 21:263-307 < Recently, several new hormonal systems have been discovered - [[leptin]] released by [[adipocytes]] (fat cells) and [[ghrelin]] released from the10 KB (1,468 words) - 09:47, 8 August 2011
- ...aisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. ''Nature''. 1998 Ma4 KB (538 words) - 07:40, 12 October 2010
- ...f GABA and NPY was confirmed at these nerve terminals.<ref name=Cowley14/> Leptin also acts at the GABA nerve terminals to reduce the inhibition of POMC neur18 KB (2,734 words) - 11:29, 19 August 2012
- <ref name="pmid15356017">{{cite journal| author=Ahima R, Osei SY| title=Leptin and appetite control in lipodystrophy. | journal=J Clin Endocrinol Metab |7 KB (899 words) - 08:12, 12 November 2010
- ''Studies the effects leptin, ghrelin and pharmacological substances have on AMPK, believed to be part o5 KB (751 words) - 10:31, 1 December 2013
- ...74:579-84</ref> Among other inputs, the reduced plasma concentrations of [[leptin]] and [[insulin]] that accompany a reduced fat mass result in an increased ...nutrient availability. Signals from the periphery (including the hormones leptin and [[insulin]]) were not increased by exercise regimes, but acute bouts o13 KB (1,945 words) - 10:47, 24 July 2011
- ...and restricted restricted offspring ate less and had higher fasting plasma leptin as adults, an adaptation which was accompanied by changes in energy sensing ...mechanisms involved, which include changes in fetal cortisol, insulin, and leptin secretion or sensitivity. Intrauterine growth retardation can be induced by33 KB (4,830 words) - 18:24, 26 July 2017
- ...to orlistat in relation to leptin, as, when using sibutramine, transfer of leptin into the brain is maintained or even increased during weight loss which doe20 KB (2,914 words) - 10:01, 20 November 2011
- ...inflammatory [[cytokines]] (such as TNF-α, IL-6, IL-1) and [[adipokines]] (leptin, adiponectin, and resistin) from [[adipocytes]]<ref name=Nar />.7 KB (1,068 words) - 16:01, 14 October 2013
- ...le cerebral artery occlusion and reperfusion by a mechanism independent of leptin deficiency. Monocyte chemoattractant protein-1 appears to contribute to the13 KB (1,805 words) - 02:37, 16 February 2010
- ...obese individuals, the [[hypothalamus]] does not respond appropriately to leptin. ...ily history of obesity, the earliest obesogenic changes are not related to leptin, but to metabolic efficiency and to insulin status and responsiveness: subj35 KB (5,127 words) - 13:28, 10 February 2023
- {{rpr|Leptin}} (31 Mar)11 KB (1,622 words) - 08:06, 25 February 2012
- ...(see also [[Hunger]]). For example, fat stores secrete a hormone called [[leptin]] that acts at the [[hypothalamus]] to regulate hormone secretion. The hypo14 KB (2,059 words) - 12:47, 6 September 2013
- ...(see also [[Hunger]]). For example, fat stores secrete a hormone called [[leptin]] that acts at the [[hypothalamus]] to regulate hormone secretion. The hypo14 KB (2,063 words) - 12:41, 6 September 2013
- ...NPY and AgRP mRNA levels in these neurons respond similarly to fasting and leptin, indicating functional redundancy of the neuropeptide systems in these orex13 KB (1,840 words) - 06:29, 13 November 2009
- .../ref><ref name=geary2004>Geary N (2004) Endocrine controls of eating: CCK, leptin and ghrelin ''Physiol Behav'' 81:719-33</ref> Initially Ghrelin was identi14 KB (2,125 words) - 10:33, 13 September 2011
- ...s an anorexigenic signal whose expression is downregulated in ''ob/ob'' ([[leptin]] deficient) mice. Following bypass surgeries (5 of 6 reported) an increase18 KB (2,561 words) - 10:26, 24 July 2011
- ...ue is as an active endocrine organ: release of [[adipokine]]s (including [[leptin]] and [[adiponectin]]), proinflammatory cytokines (IL-6 and CRP) and hypofi20 KB (2,903 words) - 10:11, 24 July 2011