Lactobacillus rhamnosus

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Lactobacillus rhamnosus GG
Scientific classification
Kingdom: Eubacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: L. rhamnosus GG
Binomial name
Lactobacillus rhamnosus GG

Description and significance

Lactobacillus rhamnosus GG (LGG) was isolated in 1983 from a healthy human and was indicated to be a strain of Lactobacillus rhamnosus by Sherwood Gorbach and Barry Goldin. The "GG" is attributed to the scientists who made this discovery. . L.rhamnosus GG is a probiotic bacteria known for its beneficial effects on the intestinal tract and can also boost a persons immune system. This helpful bacteria is said to balance the microfauna of the gastrointestinal tract. LGG can stimulate antibody production, enhances phagocytosis(a process in which an immunity cell engulfs foreign invaders), and modifies production of cytokines which are important proteins in the immune response. LGG is also known to decrease the proliferation of carcinogenic elements by other bacteria living in the intestine. In addition, in 2005 LGG was used to treat gastrointestinal carriage of vancomycin-resistant enterococci in patients with kidney problems. L. rhamnosus GG has shown to shorten the duration of rotavirus diarrhoea (Guandalini et. al 2000), relief inflammatory bowel disease (Gupta et. al 2000), and treat and prevent allergies. (Kalliomaki et al. 2001b)

Since it has so many positive effects on the human body, it is now available to buy in dairy products or in form of capsules to ingest orally.

Genome structure

The genomic sequence of Lactobacillus rhamnosus GG consists of over three million nucleotides which make up approximatly 3100 genes. Compared to other probiotic bacteria, this genome is quite large, allowing LGG to propogate a greater diversity of qualities which perhaps explains why it can benefit people in a number of different ways.

Cell structure and metabolism

Lactobacillus rhamnosus GG are a rod shaped, nonmotile aerobic bacteria thats ferments lactic acid from sugars.

Ecology

For the most part, Lactobacillus rhamnosus GG is found in the gastrointestinal tract of a human. Rarely, It has also been found in the sexually reproductive organ of women.

More info pending

Commercial Importance

Despite all of L. rhamnosus GG positive attributes and the beneficial effects it can have on the human body, it not not found in the majority of the population. However, there are several of ways to get this friendly bacteria into the gut such as eating most dairy products, as well as fruit drinks. Along with food, a person may also take pills of Dicoflor 60 which contains 6 billion LGG bacteria in one capsule. In addition to Dicoflor, there are many other companies that generate compacted capsules of L. rhamnosus such as Culturelle.

More info Pending

Dicoflor 60 capsules.

Current Research

Lactobacillus rhmnosus GG is the most studied probiotic bacteria today. A lot of research is being conducted on the effects it has on the gastrointestinal tract and the effects it has on cancer patients and people experiencing diarrhea.

Probiotics: an overview of beneficial effects

Is Lactobacillus GG Helpful in Children with Crohn's disease? Results of a Preliminary, Open-Label Study

Lactobacillus supplemaentation for diarrhoea related to study chemotherapy of colorectal cancer: a randomised study

more info pending

References

Technical Difficulties. All references will be reposted within a few days and all sections will be further contributed to.

• NCI Drug Dictionary, "Lactobacillus rhamnosus GG", National Cancer Dictionary. Retrieved on 2009-04-20
• Osterlund, P.; T. Ruotsalainen & R. Korpela (2007), "Lactobacillus supplementation for diarhoea related to chemotherapy of colorectal cancer: a randomised study", British Journal of Cancer 97: 6

Technical Difficulties. All references will be reposted within a few days and all sections will be further contributed to.