Cell surface receptor: Difference between revisions
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# Protein-tyrosine kinase receptor. There are 90 tyrosine kinases, of which 58 are cell receptors that are divided into 20 subfamilies.<ref name="pmid11114734">{{cite journal |author=Robinson DR, Wu YM, Lin SF |title=The protein tyrosine kinase family of the human genome |journal=Oncogene |volume=19 |issue=49 |pages=5548–57 |year=2000 |month=November |pmid=11114734 |doi=10.1038/sj.onc.1203957 |url=http://dx.doi.org/10.1038/sj.onc.1203957 |issn=}}</ref> An example is the [[insulin receptor]]. | # Protein-tyrosine kinase receptor. There are 90 tyrosine kinases, of which 58 are cell receptors that are divided into 20 subfamilies.<ref name="pmid11114734">{{cite journal |author=Robinson DR, Wu YM, Lin SF |title=The protein tyrosine kinase family of the human genome |journal=Oncogene |volume=19 |issue=49 |pages=5548–57 |year=2000 |month=November |pmid=11114734 |doi=10.1038/sj.onc.1203957 |url=http://dx.doi.org/10.1038/sj.onc.1203957 |issn=}}</ref> An example is the [[insulin receptor]]. | ||
# Ion channel | # Ion channel | ||
# G-protein-coupled receptor. Examples include [[angiotensin receptor]]s, [[bradykinin receptor]]s, | # G-protein-coupled receptor. Examples include [[angiotensin receptor]]s, [[bradykinin receptor]]s, [[CCR5 receptor]] (used by [[HIV]] to infect cells) [[opioid receptor]]s. | ||
==Examples== | ==Examples== | ||
Revision as of 11:39, 2 October 2008
Cell surface receptors are "proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands."[1][2] Examples are neurotransmitters and biogenic amine receptors.
Classification
Mechanistic classes include:[3]
- Protein-tyrosine kinase receptor. There are 90 tyrosine kinases, of which 58 are cell receptors that are divided into 20 subfamilies.[4] An example is the insulin receptor.
- Ion channel
- G-protein-coupled receptor. Examples include angiotensin receptors, bradykinin receptors, CCR5 receptor (used by HIV to infect cells) opioid receptors.
Examples
- For links to more information, see: Cell surface receptor: Subtopics
References
- ↑ Alberts, Bruce (2007). Molecular Biology of the Cell. Other. ISBN 0-8153-4105-9.
- ↑ Anonymous (2024), Cell surface receptors (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical Publishing Division, 18. ISBN 0-07-145153-6.
- ↑ Robinson DR, Wu YM, Lin SF (November 2000). "The protein tyrosine kinase family of the human genome". Oncogene 19 (49): 5548–57. DOI:10.1038/sj.onc.1203957. PMID 11114734. Research Blogging.