This article contains a huge amount of medical jargon. There is not one sentence that I can understand! Derek Harkness 12:01, 21 May 2007 (CDT)
No problem with "jargon", but...
What I see in this article is an attempt to comprehensively overview the structures and components of the arcuate nucleus and their fundamental functions, as well as their interconnections, and I would not change a thing.
However, the state of knowledge about the role of the arcuate nucleus (in particular) in diabetes and obesity should find its place in CZ. Would you say that it should be a subpage of arcuate nucleus? Of obesity? Type II diabetes? Hypothalamus? Would it be possible, in any of these cases, to link to these subpages from the arcuate nucleus page?
I'm eager to start an overview of the research about this topic, as it complements and assists the work I attempt to do with evolutionary medicine (sections on obesity/diabetes). I'm aware that you are an eminent specialist of these matters (hypothalamic regulation of energy homeostasis), but at the same time, I feel that if I dared to start an overview of the topic, with, for instance, Science 21 January 2005 Diabetes, Obesity, and the Brain Michael W. Schwartz and Daniel Porte,
- Hypothalamic Targets of Insulin and Leptin Action
- The arcuate nucleus, situated adjacent to the floor of the third ventricle in the mediobasal hypothalamus, contains neurons that exert potent effects on food intake, energy expenditure, and glucose homeostasis and are regulated by input from both hormonal and nutrient-related signals
you could easily point out the strengths and weaknesses of my work as it develops.
My undertanding is that the arcuate nucleus is a structure that is more vulnerable to excitotoxicity and is less protected (understandably) from blood-borne challenges. I think I have gathered good evidence about the selective vulnerability of this area in vivo, and I'm eager to present results in this field of enquiry.
Pierre-Alain Gouanvic 14:40, 14 January 2008 (CST)