From Citizendium, the Citizens' Compendium
Jump to: navigation, search
This article is a stub and thus not approved.
Main Article
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
This editable Main Article is under development and not meant to be cited; by editing it you can help to improve it towards a future approved, citable version. These unapproved articles are subject to a disclaimer.
(CC) Image: David E. Volk
IUPAC name: 4-aminobenzenesulfonamide
Synonyms: 4-aminobenzenesulfonamide
Formula: C6H8N2O2S

 Uses: antibiotic drug

 Properties: sulfonamide

 Hazards: see drug interactions

Mass (g/mol): CAS #:
172.2049 63-74-1

Sulfanilamide, often called 4-aminobenzenesulfonamide, is an antibiotic of the sulfonamide class that inhibits bacterial growth by inhibiting the production of folic acid. It competes with para-aminobenzoic acid, the natural substrate for the enzyme dihydropteroate synthetase which is essential in the folic acid cycle.

Sulfanilamide was the first clinically useful sulfonamide, no longer used due to toxicity. Gerhard Domagk, who was working on antibacterial, discovered its prototype, Prontosil, in 1935. The French researcher, Daniel Bovet, determined that only the sulfanilamide subunit of Prontosil had antibacterial.

Domagk was awarded a Nobel Prize in 1939, but the Nazi government made him refuse it.


The most up-to-date information about Sulfanilamide and other drugs can be found at the following sites.