From Citizendium, the Citizens' Compendium
Jump to: navigation, search
This article is a stub and thus not approved.
Main Article
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
This editable Main Article is under development and not meant to be cited; by editing it you can help to improve it towards a future approved, citable version. These unapproved articles are subject to a disclaimer.
Stavudine structure.jpg
IUPAC name: see Chemistry
Synonyms: Zerit®
Formula: C10H12N2O4


 Properties: thymidine-like RT inhibitor

 Hazards: see Drug interactions

Mass (g/mol): CAS #:
224.2133 3056-17-5

Stavudine is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythymidine) , antiviral drug that inhibits reverse transcriptase and is used to treat against HIV/AIDS sold under the brand name Zerit®. It is in the drug class nucleoside reverse transcriptase inhibitor (NRTI). The phosphorylated form is the active compound that competes with deoxythymidine triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group.


The IUPAC chemical name for stavudine is 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione, and it has a molecular formula C10H12N2O4, giving it a molecular mass of 224.2133 g/mol.

External links

The most up-to-date information about Stavudine and other drugs can be found at the following sites.