Psoriatic arthritis

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Psoriatic arthritis is a "type of inflammatory arthritis associated with psoriasis, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated spondylarthropathy, and the absence of rheumatoid factor" (RF).[1]

Presentation

Definitive diagnosis

The original diagnostic criteria, not involving genetic analysis, are of Moll & Wright:[2] Rheumatologists find these still somewhat vague, and also can be confounded by comorbidities. For example, a patient might have rheumatoid arthritis and have a positive rheumatoid factor test, but coincidentally have non-arthritic psoriasis. [3] There also may be hidden psoriatic lesions, and Helliwell & Taylor suggest that confirmed psoriasis in a first-degree relative may meet the criteria.

Treatment

monoclonal antibodies targeting tumor necrosis factor are the most recent therapy.

References

  1. Anonymous (2015), Psoriatic arthritis (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Moll JMH, Wright V. (1973), "Psoriatic arthritis", Semin Arthritis Rheum (no. 3): 55–78
  3. P S Helliwell, W J Taylor (2005), "Classification and diagnostic criteria for psoriatic arthritis", Ann Rheum Dis (no. 64(Suppl II)): ii3–ii8., DOI:10.1136/ard.2004.032318