Emtricitabine

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Emtricitabine structure.jpg
emtricitabine
IUPAC name: see chemistry section
Synonyms: Coviracil®, Emtriva®, Racivir®
Formula: C8H10FN3O3S

 Uses: HIV

 Properties: Reverse transcriptase inhibitor

 Hazards: see drug interactions

Mass (g/mol): CAS #:
247.2467 143491-57-0


Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) antiviral drug used to treat HIV/AIDS. Emtricitabine is a synthetic analogue of cytidine and is similar in structure to the drugs zalcitabine and lamivudine. Once the drug in converted to the triphosphate form, it works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA, by competing with the natural DNA base deoxycytidine triphosphate (dCTP). Once it is incorporated into a growing viral DNA strand, it acts as a chain terminator because it lacks a 3'-hydroxy group needed for form a phosphodiester linkage to the next incoming DNA base. It is usually used in combination with other anti-HIV drugs.

Chemistry

It IUPAC chemical name is 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and its chemical formula is C8H10FN3O3S. It is sold as a single drug under the trade names Coviracil®, Emtriva® and Racivir® and in combination with other antiviral drugs as Truvada® (with tenovir) and Sustiva® (with tenovir and efaverenz).

References


External links

The most up-to-date information about Emtricitabine and other drugs can be found at the following sites.